Reproducibility of Histologic Classification in Nonfibrotic Myeloproliferative Neoplasia

Reproducibility of histologic classification in nonfibrotic myeloproliferative neoplasia.

Early phases of polycythemia vera, essential thrombocythemia, and primary myelofibrosis (PMF) can be difficult to distinguish by morphologic studies alone because they share many morphologic characteristics. Histologic criteria according to the 2008 World Health Organization (WHO) classification are part of the myeloproliferative neoplasia (MPN) diagnosis. Our aim was to assess the reproducibil...

the role of micrornas in myeloproliferative neoplasia

mirs are 17-25 nucleotide non-coding rnas. these rnas target approximately 80% of protein coding mrnas. mirs control gene expression and altered expression of them affects the development of cancer. mirs can function as tumor suppressor via down-regulation of proto-oncogenes and may function as oncogenes by suppressing tumor suppressors. myeloproliferative neoplasias (formerly known as chronic ...

The Role of MicroRNAs in Myeloproliferative Neoplasia

MiRs are 17-25 nucleotide non-coding RNAs. These RNAs target approximately 80% of protein coding mRNAs. MiRs control gene expression and altered expression of them affects the development of cancer. MiRs can function as tumor suppressor via down-regulation of proto-oncogenes and may function as oncogenes by suppressing tumor suppressors. Myeloproliferative neoplasias (formerly known as chronic ...

Molecular Mechanisms in Philadelphia Negative Myeloproliferative Neoplasia

Classification of trophoblastic neoplasia.

A discussion of the classification of tro­ phoblastic neoplasms with clinical scien­ tists is of importance, for the work of those who direct pathology, biochemistry, en­ docrine and hematology laboratories is essential in the diagnosis and manage­ m ent of these neoplasms. Proper therapy requires the correct histopathologic diag­ nosis, monitoring of marrow, renal and marrow function and, m os...